Four centers of excellence

IDMIT (Infectious Diseases Models for Innovative Therapies) is specialized in the field of human infectious diseases and autoimmune diseases (AIDS, hepatitis B, seasonal and pandemic influenza, SARS, chikungunya, malaria, chlamydia, tuberculosis, etc.). This department is dedicated to preclinical research through the development of animal models. IDMIT houses the Imaging of Infection and Immunity Laboratory (L3i) which has the following equipment:

• PET/CT usable in level 2 or 3 microbiological containment for preclinical imaging;
• Two-photon microscope usable in level 2 or 3 microbiological containment;
• Optical imaging (near infrared camera, confocal endomicroscopy) for preclinical imaging usable in level 2 or 3 microbiological containment;
• Anatomo-pathology platform for classical histology, immunohistochemistry, immunofluorescence and in situ hybridization, mainly on immune and infectious themes.

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Dedicated to translational research on neurodegenerative diseases and retinal pathologies (Vision Institute partnership), MIRCen (Molecular Imaging Research Center) has internationally recognized expertise in gene therapy, as well as in molecular neuroimaging by PET and MRI. MIRCen teams are working on the development of animal models of human neurological pathologies (Parkinson's, Huntington's, Alzheimer's and related diseases) or ophthalmic diseases.

Once characterized, these models are used for diagnostic innovation (early diagnosis of abnormalities in the early stages of the disease) and/or for the evaluation of innovative therapies (gene therapy, cell therapy, interventional surgery, drug approaches) in the field of neurodegenerative diseases. MIRCen has the following imaging equipment:

• Two preclinical 11.7T and 7T MRIs (rodent, non-human primate) usable in level 2 or 3 microbiological containment
• Two high-resolution Focus 120 microTEP cameras for preclinical imaging in monkeys and rodents
• Optical imaging
• An ophthalmological imaging platform and multiphoton microscope dedicated to non-human primates (via an implanted team and a multi-year partnership with the Institut de la Vision).
• A radiotracer manufacturing platform for preclinical PET imaging (cyclotron/radiochemistry) which will also meet IDMIT's radiochemistry needs.

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NeuroSpin is a research infrastructure dedicated to brain neuroimaging using high-field MRI. This platform, unique in Europe, offers exceptional resources to the scientific community. It has the following imaging equipment:

• Preclinical MRI: 7T MRI, 11.7T MRI, 17.2T MRI
• Clinical MRI: 3T MRI, 7T MRI, 11.7T (prototype)
• Magnetoencephalography (MEG)
• Electroencephalography (EEG).

These technical platforms are completed by the CATI, a national image processing platform dedicated to multicenter neuroimaging studies.

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Dedicated to multimodal PET, MRI and ultrasound imaging, the SHFJ (Service Hospitalier Frédéric Joliot) provides both a diagnostic activity (nuclear medicine unit) and a research activity through the UMR BioMaps created in early 2020. The SHFJ has the following cameras/imagers dedicated to research:

• PET and hybrid imaging: small animal PET/CT, large animal PET, clinical PET/CT, clinical PET/MRI
• MRI: 1.5T clinical MRI, 7T preclinical MRI
• Ultrasound: Aixplorer ultrasound scanner (SSI) with dedicated preclinical and clinical probes.

The SHFJ is also equipped with an experimental radiopharmaceutical manufacturing platform for EU/GMP clinical PET imaging (cyclotron/radiochemistry) adapted to "phase 0" trials (microdose).

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