Translational research (from animal to humans) conducted in PASREL-imagerie centers is highlighted through several imaging techniques (PET, MRI, Ultrasound, Multimodal imaging) from different animal models to human applications. Our expertise in radiochemistry is an asset to perform either routine labelling of specific compound or custom labelling of new compound or marketed drugs.
Evaluation of a gene therapy approach in a model of Parkinson’s disease
Sars-Cov-2 model to follow up vaccine and drug effect
Monitoring connexin43 activity in the rodent brain using advanced MRI
Optimizing immunoPET imaging of tumor PD-L1 expression
Controled delivery of mAb to the mouse brain using focused ultrasound and immunoTEP
Identifying a biomarker of neuroinflammation for patient stratification in Alzheimer’s disease
Assessment of drug penetration in the brain using PET imaging
Imaging astrocyte reactivity using GluCEST MRI