Imaging techniques

• In-house isotope production (11C, 18F, 15O)
• Routine synthesis of preclinical and clinical radiopharmaceuticals
• Accreditation for the use of ⁸⁹Zr, ¹⁸F and ⁶⁴Cu isotopes
• Multimodal imaging

• Infectious diseases
• Neurodegenerative diseases
• Oncology
• Ophthalmology
• Early brain pathologies in childhood

• Preclinical and clinical R&D
• PET & multimodal imaging
• Radiotherapy
• Drugs & biomarkers
• Labeling methodology

• Long-standing experience in radiopharmaceutical and imaging agent development
• Complementary experts: biologists, physicists, pharmacologists, radiochemists, radiopharmacists, nuclear doctors, physicians
• A continuum from preclinical to clinical applications to secure the translational research
• Well-established partnerships with public and industrial players

In house production of isotopes

• ¹¹C / ¹⁸F / ¹⁵O                     Cyclone 18/9 (IBA)
• ¹¹C / ¹⁸F                              iMiTRACE (PBM)

Isotopes through suppliers

• ⁸⁹Zr                                    Perkin
• ⁶⁴Cu                                   Cyrce or Arronax
• ¹⁷⁷Lu                                   ITM radiopharm

¹¹C Radiosynthesis (6 units)

• MeI+ Research                SYNTHRA
• TRACERLab FX-C Pro    GE
• iPHASE GE

¹⁸F Radiosynthesis (5 units)

• TRACERLab FX-FN        GE
• TRACERLab FX-N Pro   GE
• All in One                         Trasis

• Translational PET imaging from preclinical to patients
• On-site isotope production (¹¹C, ¹⁵O, ¹⁸F)
• Routine synthesis of radiopharmaceuticals (list on request)
• On demand labeling of small & large molecules
• Multimodal imaging: PET/CT – PET/MRI – PET/US
• BSL 1 to 3 environment
• Complementary assets: animal housing, radiometabolite analysis and quantification, autoradiography, histology, immunohistochemistry, behavior, etc.

• Infectious diseases
• Neurodegenerative diseases
• Oncology
• Addiction
• Inflammation
• Ophthalmology

• Radiomedicine validation
• Animal model validation
• Evaluation of new therapies
• Study of drug-target interactions
• Pharmacokinetics study
• Co-registration of reconstructed 3D-histological volumes of multimodal data acquired in vivo and/or ex vivo imaging

• Long-standing experience in multimodal imaging processing
• Complementary experts: biologists, physicists, pharmacologists, radiochemists, radiopharmacists, nuclear doctors, physicians
• Well-established partnerships with public and industrial players

For preclinical purpose

• PET                                             Inveon Siemens
• PET                                             HR+ Siemens
• High-resolution PET              HRRT Siemens
• PET (2 units)                            FOCUS 220 Siemens
• PET/CT                                      Inveon Siemens
• PET/CT                                      Biograph Siemens
• PET/CT                                      Vereos Philips
• PET/MRI 3T                             SIGNA GE

For clinical purpose

• PET/MRI 3T                             SIGNA GE
• PET/CT Biograph                  Siemens
• PET HRRT                               Siemens

• High and ultrahigh field MRI from preclinical to clinical stages 
• Multimodal imaging: PET/MRI – MRI/US
• Glu-CEST imaging (Chemical Exchange Saturation Transfer for Glutamate)
• DTI, parametric imaging
• T1, T2 et T2’ ponderations
• Optimized sequences for brain spectroscopy 1H, 13C and 31P
• ZTE imaging for ¹⁷O
• BSL 1 to 3 environment
• Complementary assets: animal housing, histology, immunohistochemistry

• Infectious diseases
• Neurodegenerative diseases
• Oncology
• Ophthalmology

• Research of new contrast agents
• Animal model validation
• Evaluation of new therapies
• Anatomic and functional imaging
• Co-registration of reconstructed 3D-histological volumes of multimodal data acquired in vivo and/or ex vivo imaging

• Long-standing experience in multimodal imaging processing 
• Complementary experts: biologists, physicists, pharmacologists, radiochemists, radiopharmacists, nuclear doctors, physicians
• Well-established partnerships with public and industrial players

For preclinical purpose

• MRI 1.5T                                             Achieva (corps entier) Philips
• MRI 7T                                               Primate Agilent
• MRI 7T                                               Avance II-BGA 9 Bruker
• MRI 11.7 T                                          Rodents Bruker
• Biospec 117/16                                  Avance III Bruker
• MRI 17 T                                            17.2 T horizontal bore Bruker BioSpin
• PET/MRI 3T (Primates)                  SIGNA GE

For clinical purpose

• MRI 3T                                              Magneton Prisma fit Siemens
• MRI 7T                                              Magnetom 7T Siemens
• MRI 11.7T                                           Project ISEULT (France – Germany) dedicated to brain

• Imaging development
• Therapy approach
• Multimodal imaging: PET/US

• Clinical diagnosis in radiology (liver, kidney, muscle…)
• Brain therapy

Imaging

• Shear wave elastography
• Ultrasensitive Doppler
• Ultrafast Doppler
• Ultrafast imaging (>20 kHz)

Therapy

• Molecular contrast agent formulations and new technologies for theranostic applications
• Formulation of sono-sensitive agents
• Delivery of compounds into brain – BBB permeabilization
• Cavitation control devices during ultrasound therapy

• Long-standing experience in multimodal imaging processing
• Complementary experts: biologists, physicists, pharmacologists, radiochemists, radiopharmacists, nuclear doctors, physicians
• Well-established partnerships with public and industrial players

• Vevo F2                        Fujifilm Visualsonics
• Aixplorer Mach 30    SuperSonic Imagine
• Aixplorer Ultimate   SuperSonic Imagine
• Aixplorer                     SuperSonic Imagine
• CUBE                           Image Guided Therapy